SLC7A11 and atrial fibrillation: We provide evidence for the following: (1) GW4869 suppresses atrial electrical and structural remodeling in a pacing-induced AF model by inhibiting fibrosis, inflammation, and ferroptosis; (2) miR-23a-3p encapsulated by CFs exosomes promoting the ferroptosis of cardiomyocytes by inhibiting the transcription of SLC7A11 mRNA and depleting the Xc− transport system.