A recent study, however, showed beneficial effects from dual blockade of both IL-6 and TNF in prevention of GVHD in both MHC-mismatched and minor antigen-mismatched aGVHD murine models and in sclerodermatous cGVHD murine models (93), while preserving GVL activity against A20 (B-cell lymphoma) and C1498 (acute myeloid leukemia) (93). Here, IL6 is linked to acute myeloid leukemia.