In GVHD target tissues, blockade of IL-2β signaling increased inhibition of AKT-mTOR pathway mediated by PD-L1/PD-1 signaling, upregulated T cell expression of PD-1 and Blimp-1, and expanded IL-10+FoxP3-CD4+ Tr1 cells (156). The gene discussed is CD4; the disease is graft versus host disease.