TNF and hepatocellular carcinoma: In line with this view, our data show an increase of depolarized mitochondria in HCC-infiltrating NK cells and a decrease in potential glucose utilization, especially in the CD56BRIGHT subpopulation, translated into an inefficient cytotoxic activity, as supported by the downregulation of TNF-α and CD107a expressions and by a poor ability to establish an immunological synapse with target cells (44).