However, in this study, the 2NBDG uptake and mitochondrial mass and activity were similar among circulating CD8+ T cell subsets and no significant changes were found in T1D, indicating that the metabolic dysregulation of T1D not directly impact the basal metabolism of resting circulating T cell (23), which is not consistent with our results. This evidence concerns the gene CD8A and type 1 diabetes mellitus.