The immune infiltration score well distinguish between localized from non-localized ccRCC and had a significant positive correlation with immune microenvironmental features associated with ccRCC, including infiltration of CD8+ TILs and Tregs, the immunostimulatory factors PDCD1 and LAG-3, and the immunostimulatory factor CD27 (Figure 7B; Figure S4C). This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.