Furthermore, lower mean expression levels of FBP1 were observed in ccRCC in both cohorts than in normal tissues, while the opposite was true for TSC1. CDKN2A and CDKN2B, well-known tumor suppressors at 9p21.3, had higher transcript levels in ccRCC than normal tissue. This evidence concerns the gene CDKN2B and nonpapillary renal cell carcinoma.