In an experiment, it has been shown that ACKR2–/– mice develop experimental colitis by increased production of inflammatory chemokines (CCL3, CCL5, CXCL1, CCL2, and CXCL2) and elevated leukocyte infiltration (T cells, macrophages, B cells, and DCs) in the inflamed mucosa of the colon (60). This evidence concerns the gene ACKR2 and colitis.