It has already been stated that the B-Raf/MEK/ERK pathway mediates the downregulation of ACKR2, which leads to an increase in chemokine-mediated infiltration of macrophages and local activation of them toward a tumor-promoting M2-like phenotype (63), suggesting the importance of this pathway in the development of Kaposi sarcoma. This evidence concerns the gene ACKR2 and Kaposi's sarcoma.