It has been shown that 4-nitroquinoline-1-oxide (4NQO, a chemical carcinogen)-treated ACKR–/– mice develop high levels of IL-1β, IL-6, IL-12, IL-17, TNF-α, CCL2, CCL3, CCL4, CCL5, CCL12, CCR1, CCR2, CCR5, FGF, and VEGF in oral SCC lesions, leading to higher infiltration of Ly6G+ neutrophils, mast cells, and F4/80+ macrophages in tumor tissues and proposing an unleashed inflammation in the tumor site. This evidence concerns the gene TNF and neoplasm.