ACKR2 and breast carcinoma: Mechanistically, it has been confirmed that direct interaction of CXCL14 with ACKR2 initiates MAPK/ERK signaling and promotes EMT in SKBR3 cells, which is conversely inhibited upon downregulation of ACKR2, suggesting that CXCL14 mediates EMT and metastasis in breast cancer cells that depend on ACKR2 (27).