In addition to murine models, analysis of ACKR2+ cells in the lungs of septic patients revealed a substantial increase in the number of these cells expressing ACKR2+ compared to non-septic controls, suggesting that the elevated level of ACKR2 in septic patients is a protective response in sepsis, and a lack of ACKR2 results in increased chemokine production, neutrophil accumulation, and damage to vital organs (148). This evidence concerns the gene ACKR2 and Sepsis.