In Kaposi sarcoma, it has been shown that activation of the K-Ras-B-Raf-ERK pathway results in downregulation of ACKR2 expression, unleashing CCR2-mediated recruitment and activation of M2-like phenotype of macrophages, which support angiogenesis and tumor growth via producing VEGFA (63). This evidence concerns the gene ACKR2 and neoplasm.