In an approach described by Lamers et al., a humoral anti-idiotypic and neutralizing response was reported for an autologous CAR-T cell therapy specific to the carbonic anhydrase IX (CAIX) in metastatic renal cell carcinoma (RCC) patients (DDHK97-29/P00.0040C) (41). This evidence concerns the gene CA9 and renal cell carcinoma.