STAT3 and neoplasm: discovered that sGBM was significantly enriched with TP53 mutation, somatic hypermutation, MET-exon-14 (METex14) skipping, PTPRZ1-MET (ZM) fusion, and MET amplification; from their point of view, METex14 suppresses MET degradation and activates the Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway to promote tumor growth and angiogenesis and result in a significantly worse prognosis (15).