For instance, in glioblastoma, long non-coding RNA (lncRNA) HOTAIRM1 has been documented to upregulate the expression of HOXA1 by blocking the binding of G9a and EZH2 to histones H3K9 and H3K27, resulting in the inability of methyltransferase to methylate the promoter of HOXA1 (39). This evidence concerns the gene EZH2 and glioblastoma.