Specifically, the innate immune system is thought to play a vital role in the pathophysiology of bipolar disorder (BD) as evidenced by elevated levels of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α), acute-phase proteins, inappropriate microglial activation, and deregulation of the NRF2-KEAP1 system [3,4]. The gene discussed is TNF; the disease is Behcet disease.