Previous studies confirmed that Postn is closely related to cancer progression and may promote tumor invasion through the ILK (Integrin-linked protein kinase)/RAC-alpha serine (AKT)/Serine/threonine-protein kinase mTOR (mTOR) pathway (Zhou et al., 2015; Chen et al., 2020; Jia et al., 2021). Here, AKT1 is linked to neoplasm.