Overexpression of the OLIG2 (2.7-folds) diminishes the potassium channel (1.7-folds) activity, causing a reduction of oligodendrocyte progenitor proliferation in foetuses with DS (14–18 weeks), which may be the reason for smaller hindbrain size, developmental delay, and ID in DS by inhibiting neuronal proliferation and resulting in neuronal reduction and hypomyelination (Lu et al., 2012) (Figures 4A,B and Table 1). Here, KCNA3 is linked to Dravet syndrome.