This suggests that in the fetal stage, APP and BACE2 were not exacerbated, and overexpression of APP and BACE2 in adults with DS promotes accumulation of AβP and participates in neurodegeneration (Oyama et al., 1994; Cheon et al., 2008) (Figures 4A,B and Table 1). Here, APP is linked to Dravet syndrome.