RCAN1 was overexpressed by 1.3-folds (over 23 years) and 1.4-folds (over 50 years) in the adult brain with DS than in controls, and this chronic elevation of expression may be involved in the formation of NFTs (neurofibrilary tangles) in DS, like in AD (Ermak et al., 2001; Perluigi et al., 2014). Here, RCAN1 is linked to Dravet syndrome.