Derangement of DYRK1A-actin aggregation was found in newborns and infants with DS, suggesting that increased DYRK1A expression was related to the abnormal neuronal growth and defective neuronal circuits in brain development by reducing the actin cytoskeleton in the brain with DS, which may be associated with the ID of individuals with DS (Dowjat et al., 2012). The gene discussed is DYRK1A; the disease is Dravet syndrome.