DSCAM and Dravet syndrome: This suggests that DSCAM overexpression may be involved in abnormal neuronal projections and axonal plasma membrane (myelin-sheath) formation, causing delayed myelination and disruption of neural circuit that may be associated with the development of the ID in DS, and may also take part in the early onset of Alzheimer’s disease by disrupting axonogenesis and synaptogenesis, and senile plaque formation (Saito et al., 2000; Huang et al., 2011).