APP, BACE2, S100B, GATD3A, DOPEY2, DYRK1A, ITSN1, and SYNJ1 are involved in axonogenesis, AβP synthesis, neuronal adhesion, and neurite growth, and overexpression of this group of genes may be responsible for precautious dementia and AD-DS. This evidence concerns the gene BACE2 and Alzheimer disease.