It appears that high AFP and neutrophil-to-lymphocyte ratio (NLR) in blood are associated with poor outcome while the speed of AFP and protein induced by vitamin K absence-II (PIVKA-II) reductions is associated with OS in anti-PD1 (nivolumab or pembrolizumab) monotherapy of patients with advanced HCC (Kudo et al., 2021; Hung et al., 2021; Teng et al., 2021; Sun et al., 2021). Here, AFP is linked to hepatocellular carcinoma.