Contract with viral hepatitis B, naive B cells, resting CD4+ memory T cells, resting DCs, and activated mast cells were more broadly distributed, and plasma cells, CD8+ T cells, follicular helper T cells, γδT cells, resting NK cells, M1 macrophages, resting mast cells, and neutrophils were less evenly distributed. The gene discussed is CD4; the disease is hepatitis B virus infection.