Grade 3/4 adverse drug reactions: 84% [80–89]  Grade 3/4 hyperbilirubinemia: 49% [42–56]: (92/188, 6 with drug interruption).  Grade 3/4 lipase: 2% [0–6]  Grade 3/4 ALT: 2% [0–4]. The gene discussed is GPT; the disease is Hyperbilirubinemia.