Different abnormal tau phosphorylation events during fetal development (14–28 wk gestation) have been investigated using tau epitope-specific antibodies revealing tau positive white matter tracts (e.g., cerebellar peduncles and internal capsule) [56, 57, 80] suggesting early axonal transport defects, a common feature in tauopathies [80]. Here, MAPT is linked to tauopathy.