Although several studies have demonstrated that overexpression of cortical APP, S100B, and OLIG2 impair proliferation/neurogenesis in the fetal DS brain [49, 50], the effect that the overexpression of APP alone or in conjunction with other genes located on chromosome 21 (e.g., S100B, DYRK1A, RCAN1, OLIG1/2, SOD1) has upon FC postnatal maturation requires further investigation [7, 59]. Here, RCAN1 is linked to Dravet syndrome.