TSPO and Alzheimer disease: For the purposes of this study, 5xFAD mice were chosen as they faithfully recapitulate AD-associated Aβ pathology, and the uptake of two radiotracers, [18F]DPA-714 and [18F]FSPG, was used as a surrogate for neuroinflammation (TSPO) and oxidative stress levels (system xc-), respectively.