MAPT and Anxiety: In the instance of anxiety-like behavior, we found that introduction of P301L mutant Tau into the 5xFAD mice results in the emergence of increased anxiety-like behavior, which suggests that the interaction between the P301L mutant Tau and the underlying genetic defects could aberrantly regulate the anxiety-related brain regions (e.g. the amygdala, prefrontal cortex, and ventral hippocampus) [47].