A total of 34 predictors were available for meta-analysis, of which 15 predictors, namely, male sex, advanced age, ASA scale ≥3, anemia, COPD, coronary heart disease, arrhythmia, congestive heart failure, chronic kidney disease, cerebrovascular accident, time from injury to surgery, delayed surgery > 48 h after admission or injury, lower preoperative hemoglobin and ALB levels, lower partial pressure of oxygen in arterial blood, and higher BUN and alanine aminotransferase levels, were statistically significant. The gene discussed is ALB; the disease is anemia (phenotype).