In order to explore the potential mechanisms underlying how C2orf40 could mediate the migration ability, chemo-sensitivity, and radio-sensitivity of NPC cells, we first searched for genes which were inversely correlated with C2orf40 based on the above-mentioned GEO datasets (GSE12452, GSE53819, and GSE12452). This evidence concerns the gene ECRG4 and nasopharyngeal carcinoma.