Among them, the expression levels of cell cycle-related proteins, CCNE1 and CDK1, were negatively correlated with the expression level of C2orf40 in the three GEO datasets (Fig. 5B, C, P < 0.05), suggesting that C2orf40 was involved in the regulation of cell cycle in NPC. The gene discussed is CCNE1; the disease is nasopharyngeal carcinoma.