Hence, based on the characteristics and behavior (motor function, proinflammatory cytokine, and demyelination) and relative expression of the Dnajb1/Dnajb1/Foxp1/Tnfsf14 and Hspa4 network, we could conclude that exercise training along with 100 mg/kg Royal Jelly (ET-RJ100) had more effect on the Multiple sclerosis condition. This evidence concerns the gene DNAJB1 and multiple sclerosis.