Singleton pregnancy16.0–25.9 weeks of gestationSevere LUTO defined as the presence of a megacystis on ultrasoundFetal urine β‐2 microglobulin value below the reference level (6.3–11.2 mg/L)*Re‐accumulation of urine in the bladder after vesicocentesisNo renal cystic changesNo other severe congenital malformations. This evidence concerns the gene HLA-G and pregnancy disorder.