In the mouse model of CVB3-induced viral myocarditis, dapagliflozin inhibits the production and release of inflammatory cytokines IL-1β, IL-6, and TNF-α, inhibiting macrophage polarization toward M1-type, reducing inflammatory infiltration, and significantly improving the survival rate of mice, these effects were depended on the activation of Stat3 signal pathway. The gene discussed is IL6; the disease is viral myocarditis.