PAX8 and nonpapillary renal cell carcinoma: Furthermore, knockdown of MYC expression to the level observed in HNF1B-depleted cells closely phenocopied the effect of HNF1B inhibition on ccRCC proliferation in vitro (Extended Data Fig. 10f, g), and HNF1B restoration in PAX8-depleted cells restored MYC expression (Fig. 4c).