In line with this, the HIF2A motif was the most significantly enriched motif in ccRCC-specific peaks from assay of transposase accessible chromatin sequencing (ATAC-seq) when compared to papillary RCCs in the The Cancer Genome Atlas (TCGA) cohort23 (Extended Data Fig. 4d, e). Here, EPAS1 is linked to nonpapillary renal cell carcinoma.