In addition to renal cancer, E8:128132 and E8:128526 showed DNA accessibility in normal cells derived from the kidney (Fig. 4h), and PAX8 depletion inhibited the proliferation of HK2 cells, a renal epithelial cell line, and normal human renal organoids (Fig. 4i,j and Extended Data Fig. 11e). This evidence concerns the gene PAX8 and renal carcinoma.