ADAM17 and anaplastic large cell lymphoma: Eight candidate genes were selected for further validation including the four strongest downregulated genes (PSENEN, SRPRB, ZNF275, PNPO), and four genes with high expression and known oncogenic functions related to ALK+ ALCL (BSG/CD147, CASP2, ADAM17, PIK3AP) (Supplementary Table 1, Supplementary Fig. 4).