To investigate whether the expression of CD147 and miR-146a were ALK-dependent, two ALK+ ALCL cell lines where treated with increasing concentrations of Crizotinib, which led to inhibition of P-ALK and P-STAT3 with subsequent increase in miR146a (Fig. 2F), and decrease in CD147 (Fig. 2G, H). The gene discussed is ALK; the disease is anaplastic large cell lymphoma.