Eight candidate genes were selected for further validation including the four strongest downregulated genes (PSENEN, SRPRB, ZNF275, PNPO), and four genes with high expression and known oncogenic functions related to ALK+ ALCL (BSG/CD147, CASP2, ADAM17, PIK3AP) (Supplementary Table 1, Supplementary Fig. 4). The gene discussed is CASP2; the disease is anaplastic large cell lymphoma.