As seen, there are a diverse set of drug categories, in addition to estrogens, calcium channel blockers, gamma-aminobutyric acid (gaba), androgen, serotonin, adrenergic, glucocorticoid receptor agonist/antagonist; inhibitors of JAK2, MDM2, HDAC, SRC, PI3K, EGFR, RAF, JNK, PLK, p38Mapk, VEGFR, MEK, FLT3, CDK, AKT, HSP, NFkB, IKK; HIV integrase inhibitor, DNA/RNA synthesis inhibitors; and tyrosine, map, aurora kinase inhibitors; corticosteroid agonist, immunosuppressants; SSRI (anti-depression) inhibitors, platelet aggregation inhibitors, as well as tubulin, microtubule inhibitors. This evidence concerns the gene NFKB1 and major depressive disorder.