In these genes, we found protumorigenic genes, including KCNN4 (R = 0.78; Fig. 5e), inducing cell proliferation in breast cancer34, and IGF1R (R = 0.74; Fig. 5f), promoting ER+ breast cancer metastasis and endocrine resistance by modulating multiple kinase activities35–37, suggesting that the gene regulatory elements are possibly associated with cellular programs for cancer progression. This evidence concerns the gene KCNN4 and breast cancer.