Boon et al. [42] reported that insulin resistance induced by 5 days of HCHF feeding (as assessed by HOMA-IR) also increased the expression of various macrophage markers (for example cluster of differentiation CD68, CD14 and CD11c) in skeletal muscle and reduced the markers of insulin signalling (solute carrier family transporter SLC2A and glycogen synthase-1). The gene discussed is INS; the disease is Insulin resistance.