ZC3HAV1 and viral infectious disease: The IFN-inducibility of the long isoform of ZAP (Schwerk et al. 2019; Nchioua et al. 2020) may indeed induce a hostile internal milieu in cells challenged by virus infection where high levels of ZAP expression may suppress global gene expression and bias gene expression toward genes with oversuppressed CpG frequencies, such as those for IFNs and thereby enhancing the cellular anti-viral state.