TNIK kinase is essential in the activation of the β-catenin pathway and many CRC patients with advanced stages II and III have been shown to have elevated TNIK protein levels.[22] It is recruited to the promoters of the Wnt target genes and directly phosphorylates TCF4.[23,24] However, TNIK is a multifunctional protein,[25,26] and its role is not limited to modulating Wnt signaling. The gene discussed is TCF4; the disease is colorectal carcinoma.