Indeed, the role of TNIK in modulating immune cells either by affecting β-catenin transcription in T-cell differentiation[6] or via the canonical NF-κB and c-Jun N-terminal kinase (JNK) activation in B-cells have been reported.[26] Our in vitro experiment shows that both NCB0846 and MBZ can directly activate CD8+ T-cells independently of immunogenic tumor cell death. Here, CD8A is linked to neoplasm.