In models of focal (Cao et al., 2014, 2017; Janyou et al., 2017, 2020; Wu et al., 2017) and global (Junyun et al., 2016; Zhong et al., 2018) cerebral ischemia, several biochemical effects of DHC have been reported that are difficult to disentangle from hypothermia per se. Critically, however, the salutary effects of DHC in ischemia are not observed in TRPV1 knockout mice, strongly implicating TRPV1 as a principal mechanism of action (Cao et al., 2014). The gene discussed is TRPV1; the disease is ischemia.