IFNA1 and viral infectious disease: However, a more potent induction of antiviral IFNs by saliva did not account for its ability to modulate virus infection, as the enhancement of both SFV and ZIKV infection by Aedes saliva was IFN independent (Fig. 4C, for SFV; Fig. 3A and SI Appendix, Fig. S4C, for ZIKV).