However, a more potent induction of antiviral IFNs by saliva did not account for its ability to modulate virus infection, as the enhancement of both SFV and ZIKV infection by Aedes saliva was IFN independent (Fig. 4C, for SFV; Fig. 3A and SI Appendix, Fig. S4C, for ZIKV). Here, IFNA1 is linked to Zika virus infectious disease.