In vertebrate models, mutation or loss of zebrafish (Danio rerio) orthologs of apicobasal polarity proteins EPB41L5 (zebrafish moe) [61,62], MPP5 (nok) [63], and CRB2 (ome) [64] cause retinal developmental and lamination abnormalities similar to Crb1-associated retinal dysplasia. The gene discussed is STYK1; the disease is Retinal dysplasia.