Deficits in mouse CRB1 [19,20,23], CRB2 [65–67], CRB1 and CRB2 combined [42,52,67], MPP5 [68], and PRKCI [69] have similar effects, supporting the hypothesis that defects in apicobasal polarity cause retinal dysplasia. Here, CRB2 is linked to Retinal dysplasia.