Cx3cr1, Mthfr, and Cygb were identified as modifiers of Crb1rd8 retinal dysplasia [38–40], Jak3 as an enhancer of a Crb1rd8-dependent neovascular phenotype [41], and Crb2 as a modifier of retinal dysplasia due to a Crb1 knock-out allele [42,43]. The gene discussed is CRB2; the disease is Retinal dysplasia.