2010; Husen et al. 2021; Ratnaningtyas et al. 2021). As a result, it is strongly suggested that C. comatus protects the pancreas, lowers blood glucose, and increases insulin and GLP-1 levels in STZ-induced diabetes mellitus rats by inhibiting DPP-4 and attenuating ROS. The gene discussed is GCG; the disease is diabetes mellitus.