For example, the lncRNA IGF2-AS, as an antisense gene of IGF2, inhibits the tumorigenesis of breast cancer by epigenetically regulating IGF2 and affects the metastasis and prognosis of gastric adenocarcinoma by sponging miR-503 to regulate SHOX2 [28, 29]. This evidence concerns the gene SHOX2 and gastric adenocarcinoma.