These three interact to ultimately recruit Th2 and regulatory T cells, which mediate immunosuppressive effects; and secrete a variety of cytokines, growth factors (e.g. EGF, VEGF, PDGF, FGF and TGFβ), which interact with and influence multiple cell types in the tumor microenvironment and, in turn, mediate complex effects. This evidence concerns the gene TGFB1 and neoplasm.