Proinflammatory cytokines (interleukin and tumor necrosis factor-mediated signaling pathways) are regulated by the expression of immune-related microRNAs and associated with colorectal tumor progression, which can be considered as biomarkers of colorectal cancer (immune microenvironment of colorectal tumors: involvement of immune genes and microRNAs belonging to the TH17 pathway). This evidence concerns the gene TNF and colorectal neoplasm.