The IRS of intra-cellular E-cadherin (median 9, IQR 4.5–9), N-cadherin (median 12, IQR 7.5–12) and the proportion of tumours with nuclear E-cadherin (29%) in the corticotroph functioning PitNETs did not appear statistically different (p = 0.20, p = 0.40 and p = 0.44, respectively) from the corticotroph NF-PitNETs (data presented in Table 1B). The gene discussed is CDH2; the disease is neoplasm.