NLRP3 and Parkinson disease: Other studies have shown an activation of NLRP3 inflammasome in distinct α-syn PD models, including primary monocytes and primary microglia exposed to fibrillar α-syn, mouse striatum subjected to 6-OHDA treatment, α-syn pre-formed fibrils (PFF)-injected mice, post-mortem SN sections from PD brains and also blood and CSF samples from PD patients [68, 69, 70•].