Even more interestingly, a mouse model of multiple sclerosis showed that endothelial expression of ACKR3 at the central nervous system (CNS) vasculature was increased during inflammation and the antagonism of ACKR3 dampened leukocyte infiltration into the CNS parenchyma resulting in improved the clinical severity of the disease model [10]. The gene discussed is ACKR3; the disease is multiple sclerosis.