All responses against infections initiate when the innate immune system detects pathogen-associated molecular patterns (PAMPs) expressed by invading microorganisms using pattern recognition receptors (PRRs) such as the Toll-like receptors (TLRs), NOD-like receptors (NLRs), retinoic-acid-inducible gene 1 (RIG-1), among others (Eisenbarth and Flavell 2009). This evidence concerns the gene PLAAT4 and infection.