The study showed no statistically significant differences in the monitoring of infection markers such as LDH (p=0.968), lactic acid (p=0.133) and CRP (p=0.669) between the groups, nor did it show any statistically significant association between the insulin therapy techniques used and the diagnosis of nosocomial infection (p=0.726), and length of hospital stay (p=0.322). This evidence concerns the gene INS and nosocomial infection.