CHEK1 and gastric cancer: On the one hand, JB causes DNA damage in gastric cancer MKN45 cells and induces the S cycle arrest by activating the ATR-CHK1-CDC25A-Cdk2 signaling pathway, On the other hand, JB induces MKN45 cells apoptosis through the mitochondrial pathway, and ultimately effectively inhibits the growth of gastric cancer cells.