It should also be noted, however, that senescence of fibroblasts caused by prolonged exposure to CDK4/6 inhibitor can accompany the SASP that increases and decreases the population of Gr‐1‐positive immune cells and CD3‐positive cells in the tumour microenvironment, respectively, and promotes melanoma growth in mice due to the suppression of anti‐tumour immunity [110]. The gene discussed is CDK4; the disease is neoplasm.