EGFR and non-small cell lung carcinoma: For instance, SOX2-OT acts as a miR-627-3p sponge to promote Smads expression and is associated with the EGFR-TKIs resistance in NSCLC cell line H1975 [31]; in NSCLC cell lines A549 and H1299, SOX2-OT promotes cell migration and invasion by sponging to miR-132 [32].