These results demonstrated that the gastrin/CCKBR-mediated amelioration of salt-sensitive hypertension-related genes, and thus hypertension, is via a reduction of NHERF1-NHERF2-induced small intestinal brush border membrane NHE3 trafficking, through a PLC/PKC-dependent pathway (Figure 6). The gene discussed is NHERF1; the disease is hypertensive disorder.