In line with this, we also found expression of RNAPOL1 subunits and associated factors upregulated in five different CRC cell lines (DLD1, HCT116, HT29, LS174t, SW480) harboring oncogenic activation of the WNT pathway by either APC or beta‐catenin mutation in addition to additional mutations in CRC associated genes, relative to normal colon mucosa [23, 24] (Fig. S1D). Here, CTNNB1 is linked to colorectal carcinoma.