CCL15 was also increased as the pseudo-time progressed and was dominant in the end stages of the pseudo-time axis; Conversely, other key molecules such as IGHG1, IGHG3, IGHG4, IGKC, IGLC2 decreased gradually among all the carcinoma sectors in HCC1 and HCC4 (Figure S3C-D). This evidence concerns the gene IGHG4 and carcinoma.