Previous studies showed that CCL21 can affect tumor progression by recruiting immune cells such as T lymphocytes 46, 47, and have reported that tumor-infiltrating B cells may inhibit liver cancer progression and improve prognosis by interacting with CD4+ T cells in close proximity and subsequently activating CD8+ T cells, but the origins of tumor-infiltrating T cells and B cells are still unclear. Here, CD4 is linked to liver cancer.