FXYD5 and intestinal neoplasm: Using an antibody that specifically recognizes the active conformation of murine β1 integrin (clone 9EG7) 31, we confirmed the role of dysadherin in regulating β1 integrin activation in intestinal tumors of ApcMin/+;Fxyd5-/- mice and ApcMin/+;Fxyd5+/+ mice, showing a striking reduction in β1 integrin activation in the absence of dysadherin (Figure 3F).