In the azoxymethane/dextran sodium sulfate (AOM/DSS)-induced intestinal tumorigenesis mouse model19, 26, we also detected the presence of dysadherin expression in EpCAM+ intestinal tumor epithelial cells, whereas no dysadherin expression was observed in epithelial cells within normal intestines (Figure S2E). Here, FXYD5 is linked to intestinal neoplasm.