In the ApcMin/+ mouse model 18, 25, histological assessment of ApcMin/+ mice revealed the acquisition of dysadherin expression in epithelial cell adhesion molecule-positive (EpCAM+) epithelial cells residing within intestinal tumors, whereas no dysadherin expression was observed in epithelial cells within normal intestines (Figure 1A). This evidence concerns the gene FXYD5 and intestinal neoplasm.