FN1 and colorectal carcinoma: Since autonomous secretion of fibronectin from CRC cells induced fibronectin binding to dysadherin-expressing CRC cells to generate phenotypic changes in the cells (Figure 4C and Figure S9 and S10), we decided to further confirm whether phenotypic changes detected on a 0.5 kPa hydrogel are caused by fibronectin binding to dysadherin.