Conversely, when we explored the stromal effect of dysadherin depletion on tumorigenesis by inoculating murine intestinal tumor cells (MC38) 27 into Fxyd5+/+ and Fxyd5-/- mice, we found that dysadherin-KO physiological environment did not affect tumor seeding and growth (Figure S3A-C). Here, FXYD5 is linked to intestinal neoplasm.