While dysadherin is frequently overexpressed in a broad range of human cancers, including thyroid, esophageal, gastric, colorectal, pancreatic, cervical, testicular, breast, and head and neck tumors, dysadherin surface expression is limited in normal cells, and dysadherin is rarely expressed on non-neoplastic cells 1-11. This evidence concerns the gene FXYD5 and head and neck neoplasm.