WNT1 and renal fibrosis: In contrast to profibrotic role of Wnt1 in cardiac repair, our findings not only support the antifibrotic roles of Wnt4 that are consistent with the findings of some previous studies indicating the potential antifibrotic role of Wnt4 in skin and renal fibrosis 32,33, but also support the proendothelial roles of Wnt4 that are also consistent with some previous studies that mesenchymal stem cells can improve cardiac function after cardiac injury by regulating endothelial cells via the Wnt4 35,36.