The combinatory anti-growth effects of METAP1, METAP2 or USP7 knockdown and PI3K inhibition were also evident in other human cancer cells, namely two CRC (LoVo-TA and Caco2-TA) as well as two HCC (HuH7-TA; HEP-3B-TA) cell lines (Supplementary Figures S9-S11and S21). The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.