Introduction of inducible knockdown constructs into human colorectal adenocarcinoma ([CRC]; Caco2-TA, LoVo-TA) as well as human hepatocellular carcinoma ([HCC]; HuH7-TA, HEP-3B-TA) cell lines yielded in a potent knockdown of METAP1 or METAP2 after 4 and 8 days of Dox treatment (Supplementary Figures S7A/B and S8A/B). Here, METAP2 is linked to colorectal carcinoma.