RGS16 and lung cancer: In melanoma cells Usp7 inhibition was shown to increased expression of protein phosphatase 2 subunitBR3 isoform (PPP2R3A), which is known to dephosphorylate Akt 113 and in lung cancer cells Usp7 inhibition led to decreased levels of phosphorylated S6 (Ser235/236) as well as upregulation of two mTOR inhibitor proteins (FKBP11 and RGS16; 114).