For instance, the exosome-mediated transfer of miR-210 from fibroblasts to endothelial cells promotes angiogenesis and tumor growth in lung cancer 12; exosomes derived from tumor-associated macrophages promote angiogenesis and cervical cancer progression by delivering TIE2 13; exosomal HMGB1 derived from hypoxia-conditioned bone marrow mesenchymal stem cells enhances angiogenesis through the JNK/HIF-1α signaling pathway 14. Here, HIF1A is linked to neoplasm.