To further determine the role of EPHA2 in breast cancer patients, immunohistochemical staining was used to examine the expression of EPHA2 and CD31 in a breast cancer tissue microarray, including 8 cases of paraneoplastic tissues, 28 cases of non-metastatic tissues and 19 cases of metastatic breast cancer tissues. This evidence concerns the gene EPHA2 and breast carcinoma.