To further determine whether exosomal EPHA2-mediated angiogenesis is required for breast cancer metastasis in vivo, LM and HM breast cancer cells, control cells and EPHA2-silenced HM cells were subcutaneously injected into the fat pad of SCID mice to establish xenograft tumor models (Figure 6A). The gene discussed is EPHA2; the disease is breast carcinoma.